Premature Ovarian Insufficiency (POI) is a multi-factorial disorder that affects women of reproductive age.The condition is characterized by the loss of ovarian function before the age of 40 years and several factors have been identified to be implicated in its pathogenesis.Remarkably though, at least 50% of women have remaining follicles in their
Overview of OTFS Based Channel Estimation Techniques in LEO Satellite Communication
With the development of science and technology and the continuous improvement of related technologies, low earth orbit (LEO) satellite communication has become a hot technology that countries all over the world are chasing.The advantages of orthogonal time frequency spacetechnology can well solve the signal transmission problem of broadband satelli
A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis
Background: Glucocorticoids (GCs) are commonly used Vanity Chairs as the primary chemotherapy for lymphoid malignancies, including acute lymphoblastic leukemia (ALL).However, the development of GC resistance limits their prolonged use.Methods: In this study, we investigated the potential of a newly synthesized indole derivative called LWX-473, in c
Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier
AIM: To investigate the role of oxidative stress in regulating the functional expression of P-glycoprotein (P-gp) in mitochondria of D407 cells.METHODS: Denim D407 cells were exposed to different ranges of concentrations of H2O2.The mitochondrial location of P-gp in the cells subjected to oxidative stress was detected by confocal analysis.Expressio